https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32623 Tue 26 Jun 2018 11:28:33 AEST ]]> ScNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34876 Tue 03 Sep 2019 18:18:22 AEST ]]> A Menin-MLL inhibitor induces specific chromatin changes and eradicates disease in models of MLL-rearranged leukemia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36614 Thu 28 Oct 2021 12:37:17 AEDT ]]> Genome-wide analysis of DNA methylation in single cells using a post-bisulfite adapter tagging approach https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45991 Thu 10 Nov 2022 10:14:22 AEDT ]]> The Promise of Single-cell Technology in Providing New Insights into the Molecular Heterogeneity and Management of Acute Lymphoblastic Leukemia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52222 Thu 05 Oct 2023 10:30:50 AEDT ]]> scTEM-seq: Single-cell analysis of transposable element methylation to link global epigenetic heterogeneity with transcriptional programs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50787 Sat 05 Aug 2023 11:22:45 AEST ]]> Smchd1 is a maternal effect gene required for genomic imprinting https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42368 Mon 22 Aug 2022 14:08:45 AEST ]]> Single-cell epigenomics in cancer: Charting a course to clinical impact https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42366 Mon 22 Aug 2022 14:08:36 AEST ]]> Crosstalk between DNA methylation and hypoxia in acute myeloid leukaemia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52306 Mon 09 Oct 2023 10:16:43 AEDT ]]> Genome-scale oscillations in DNA methylation during exit from pluripotency https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35158 in vitro and in vivo. Exit from pluripotency and priming for differentiation into somatic lineages is associated with genome-wide de novo DNA methylation. We show that during this phase, co-expression of enzymes required for DNA methylation turnover, DNMT3s and TETs, promotes cell-to-cell variability in this epigenetic mark. Using a combination of single-cell sequencing and quantitative biophysical modeling, we show that this variability is associated with coherent, genome-scale oscillations in DNA methylation with an amplitude dependent on CpG density. Analysis of parallel single-cell transcriptional and epigenetic profiling provides evidence for oscillatory dynamics both in vitro and in vivo. These observations provide insights into the emergence of epigenetic heterogeneity during early embryo development, indicating that dynamic changes in DNA methylation might influence early cell fate decisions.]]> Fri 21 Jun 2019 15:13:02 AEST ]]> Unravelling the epigenome of myelodysplastic syndrome: diagnosis, prognosis, and response to therapy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44495 Fri 14 Oct 2022 09:46:45 AEDT ]]> Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51359 Fri 01 Sep 2023 13:44:11 AEST ]]>